Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 39, Issue -, Pages 132-138Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.12.005
Keywords
Smac mimetic; IAP proteins; Cell death; Cancer
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Funding
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- IUAP
- Wilhelm-Sander Stiftung
- BMBF
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As the Inhibitor of Apoptosis (IAP) proteins are expressed at high levels in human cancers, they represent promising targets for therapeutic intervention. Small-molecule inhibitors of IAP proteins mimicking the endogenous IAP antagonist Smac, called Smac mimetics, neutralize IAP proteins and thereby promote the induction of cell death. Smac mimetics have been shown in preclinical models of human cancer to directly trigger cancer cell death or to sensitize for cancer cell death induced by a variety of cytotoxic stimuli. Smac mimetics are currently undergoing clinical evaluation in phase I/II trials, demonstrating that therapeutic targeting of IAP proteins has reached the clinical stage. (C) 2015 Elsevier Ltd. All rights reserved.
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