Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 47-48, Issue -, Pages 74-79Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.09.006
Keywords
Preimplantation mouse embryos; Cell lineage; Hippo pathway; Cell geometry; Mechanical forces; Computational modelling
Categories
Funding
- BBSRC [BB/J00989X/1, BB/E004946/1]
- Wellcome Trust [103788/Z/14/Z]
- 1851 Royal commission
- Trinity Hall Cambridge
- Oxford Stem Cell Institute Fellowship from the Oxford Martin School
- BBSRC [BB/E004946/1, BB/J00989X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E004946/1, BB/J00989X/1] Funding Source: researchfish
- Wellcome Trust [103788/Z/14/Z] Funding Source: researchfish
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The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under investigation and have variously been considered to be completely stochastic or alternately, subject to some predisposition set up at fertilisation or before. Here, we consider these views in light of recent publications, discuss the possible role of cell geometry and mechanical forces in this process and describe how modelling could contribute in addressing this issue. (C) 2015 The Authors. Published by Elsevier Ltd.
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