Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 39, Issue -, Pages 91-96Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.12.007
Keywords
Survivin; IAP; Cell division; Apoptosis; Cancer; Mitotic catastrophe
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Funding
- National Institutes of Health (NIH) [P01 CA140043, R01 CA78810, CA190027]
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Although technically a member of the Inhibitor of Apoptosis (IAP) gene family, survivin has consistently defied assumptions, refuted predictions and challenged paradigms. Despite its more than 5500 citations currently in Medline, the biology of survivin has remained fascinatingly complex, its exploitation in human disease, most notably cancer, tantalizing, and its regulation of cellular homeostasis unexpectedly far-reaching. An inconvenient outsider that resists schemes and dogmas, survivin continues to hold great promise to unlock fundamental circuitries of cellular functions in health and disease. (C) 2015 Elsevier Ltd. All rights reserved.
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