4.6 Review

Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression

Journal

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 40, Issue -, Pages 60-71

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.02.008

Keywords

Extracellular vesicles; Exosomes; Epithelial-mesenchymal transition; EMT; Cancer progression; Microparticles

Funding

  1. National Health and Medical Research Council of Australia [487922]
  2. Melbourne Research Grant Support Scheme (Melbourne University)
  3. Early Career CJ Martin Fellowship [APP1037043]
  4. La Trobe University Postgraduate Scholarship
  5. Melbourne International Research Scholarship (Melbourne University)
  6. [1057741]
  7. [628727]

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Epithelial-mesenchymal transition (EMT) is a highly conserved process defined by the loss of epithelial characteristics, and acquisition of the mesenchymal phenotype. In addition to its central role in development, EMT has been implicated as a cellular process during tumourigenesis which facilitates tumour cell invasion and metastasis. The EMT process has been largely defined by signal transduction networks and transcriptional factors that activate mesenchymal-associated gene expression. Knowledge of secretome components that influence EMT including secreted proteins/peptides and membrane-derived extracellular vesicles (EVs) (i.e., exosomes) has emerged. Here we review EV cargo associated with inducing the hallmarks of EMT and cancer progression, modulators of cell transformation, invasion/migration, angiogenesis, and components involved in establishing the metastatic niche. (C) 2015 Elsevier Ltd. All rights reserved.

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