Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 40, Issue -, Pages 115-126Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.03.005
Keywords
Autophagy; Neurodegeneration; Parkinson; Alzheimer; Huntington; Rapamycin
Categories
Funding
- Fondo de Investigacion Sanitaria-Instituto de Salud Carlos III, Spain [CP09/00184, PI14/01529]
- CIBERNED
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Neuronal homeostasis depends on the proper functioning of quality control systems like autophagy. This mechanism is responsible of the clearance of misfolded proteins, aggregates and the turnover of organelles within the neuron. Autophagic dysfunction has been described in many neurodegenerative diseases. It can occur at several steps of the autophagic machinery and can contribute to the formation of intracellular aggregates and ultimately to neuronal death. Accordingly restoring autophagy activity in affected neurons can be an attractive therapeutic approach to fight neurodegeneration. In this review we summarize the present encouraging strategies that have been achieved with pharmacological and genetic treatments aimed to induce neuronal autophagy in experimental models of neurodegenerative diseases. (C) 2015 Elsevier Ltd. All rights reserved.
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