Journal
SEMINARS IN CANCER BIOLOGY
Volume 35, Issue -, Pages S25-S54Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2015.02.006
Keywords
Proliferation; Natural products; Therapeutic targets; Cancer stem cells; Cancer hallmarks
Categories
Funding
- NIH [AI076535, R01 CA109335-04A1, R01CA131294, CA155686, K01DK077137, R03DK089130]
- Temple University
- National Science Foundation
- American Cancer Society
- University Roma Tre (CLA)
- Italian Association for Cancer Research [IG15221]
- EU [MC-CIG-303514]
- Greek National funds through the Operational Program 'Educational and Lifelong Learning of the National Strategic Reference Framework (NSRF)-Research Funding Program: THALES [MIS 379346]
- COST Action CM1201 'Biomimetic Radical Chemistry'
- Italian Ministry of University
- University of Italy
- Terry Fox Foundation [TF-36]
- UAEU Program for Advanced Research [UPAR25183]
- Al-Jalila Foundation [AJF201454]
- Zayed Center for Health Sciences [ZCHS2014]
- FEDER
- MICINN [SAF2012-32810]
- Junta de Castilla y Leon [BIO/SA06/13]
- ARIMMORA project (FP7-ENV, EU 7th Framework Program)
- EuroSyStem
- DECIDE Network (EU FP7)
- Avon Foundation
- Breast Cancer Research Foundation [90047965]
- Fast Track Scheme for Young Scientists, Department of Science and Technology, India [SR/FT/LS-063/2008]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [24590493]
- Italian Association for Cancer Research (AIRC) [IG10636]
- MIUR-PRIN [20125S38FA_002]
- Ministero della Salute [GR-2011-02348047]
- Ovarian
- Purdue University Center for Cancer Research
- University of Glasgow
- Beatson Oncology Centre Fund
- Cancer Research UK [C301/A14762]
- Prostate Cancer Research Trust, UK
Ask authors/readers for more resources
Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression. (C) 2015 Elsevier Ltd.
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