Journal
SEMINARS IN CANCER BIOLOGY
Volume 33, Issue -, Pages 34-39Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2015.04.001
Keywords
UPR; Nutrient shortage; Metabolism; HBP
Categories
Funding
- Institut National du Cancer [INCA-7981]
- Ligue Nationale Contre le Cancer (Comite du rhone)
- Fondation ARC pour la recherche sur le cancer [PJA20131200334]
- Plan Cancer
- Fondation de France
- Canceropole PACA
- Ligue Nationale contre le Cancer
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Both the hexosamine biosynthetic pathway (HBP) and the endoplasmic reticulum (ER) are considered sensors for the nutritional state of the cell. The former is a branch of the glucose metabolic pathway that provides donor molecules for glycosylation processes, whereas the second requires co-translational N-glycosylation to ensure proper protein folding. It has become clear that the microenvironment of solid tumours, characterised by poor oxygen and nutrient supply, challenges optimal functions of the ER and the HBP. Here, we review recent advances demonstrating that the ER stress (ERS) response and HBP pathways are interconnected to promote cell viability. We then develop the idea that communication between ER and HBP is a survival feature of neoplastic cells that plays a prominent role during tumourigenesis. (C) 2015 Elsevier Ltd. All rights reserved.
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