Journal
SEMINARS IN CANCER BIOLOGY
Volume 33, Issue -, Pages 67-73Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2015.04.007
Keywords
Endoplasmic reticulum; Cancer; Stress; Tumor; EMT
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Funding
- Institut National du Cancer (INCa)
- Ligue Contre le Cancer
- Fondation de France
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The hallmarks of cancer currently define the molecular mechanisms responsible for conferring specific tumor phenotypes. Recently, these characteristics were also connected to the status of the secretory pathway, thereby linking the functionality of this cellular machinery to the acquisition of cancer cell features. The secretory pathway ensures the biogenesis of proteins that are membrane-bound or secreted into the extracellular milieu and can control its own homeostasis through an adaptive signaling pathway named the unfolded protein response (UPR). In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness. (C) 2015 Elsevier Ltd. All rights reserved.
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