Journal
SEMINARS IN CANCER BIOLOGY
Volume 35, Issue -, Pages 200-211Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2015.07.001
Keywords
microRNAs; Stem cells; ES; IPS; MSC; Cancer stem cells; Metastasis
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Funding
- Deutsche Krebshilfe/Dr. Mildred-Scheel-Stiftung
- Alfried Krupp von Bohlen und Halbach Foundation (Essen, Germany)
- Hella Buhler Foundation (Heidelberg, Germany)
- Dr. Ingrid zu Solms Foundation, (Frankfurt/Main, Germany)
- FRON-TIER Excellence Initiative of the University of Heidelberg
- Walter Schulz Foundation (Munich, Germany)
- German-Israeli Project Cooperation DKFZ-MOST (Ministry of Science and Technology)
- Wilhelm-Sander Foundation (Munich, Germany)
- HIPO/POP-Initiative
- German Research Council (DFG)
- German Cancer Aid (Max-Eder Research Group)
- Baden-Wurttemberg Foundation
- German Center for Cardiovascular Disease (DZHK)
- Leading National Research Centre (KNOW) in Bialystok, Poland
- DKFZ Heidelberg
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MicroRNAs now not only represent a significant mechanism for post-transcriptional gene regulation, but have come to be appreciated as molecules with far reaching tentacles affecting diverse processes and pathologies by modulating amongst others, cellular gene expression, epigentic mechanisms, complex signaling cascades, cell-cell communication, the immune system and microenvironmental interactions between several cell types, tissues and organ systems. In this review, we systematically reflect on the impact of miRNAs on all types of benign and malignant human stem cells, looking at the roles they play in maintaining or changing the stem cell state, and review how aberrations of their expression and function within diverse types of stem cells orchestrate carcinogenesis and metastasis. As a conclusion, we consider it striking to see how similar some miR-driven mechanisms are between different types of stem cells and cancer cells, and how this might support hypotheses of miR-driven embryologic pathway reactivation in metastasis or propose putative functions of miRs in important novel cross-topic fields such as obesity and cancer. (C) 2015 Elsevier Ltd. All rights reserved.
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