Journal
MONATSHEFTE FUR CHEMIE
Volume 145, Issue 7, Pages 1089-1099Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-014-1197-6
Keywords
Antimicrobial activity; Antioxidants; Cytotoxicity; Coordination chemistry; Schiff bases
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Funding
- Ministry of Education, Science, and Technological Development of the Republic of Serbia [OI 172055, III 41025, III 46010]
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New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.
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