Journal
MONATSHEFTE FUR CHEMIE
Volume 144, Issue 5, Pages 647-658Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-012-0888-0
Keywords
Sulfonamidine; Heterocycles; Crystal structure; Antimicrobial activity; Antitumor activity; Structure-activity relationship
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A series of novel heterocyclic sulfonyl-carboximidamides were synthesized in satisfactory yields via condensation of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. New structures were confirmed by IR and NMR spectra as well as elemental analyses. X-ray crystallography of two derivatives was performed. The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. All the compounds were screened for their tuberculostatic, antibacterial, and anticancer activities. Preliminary results indicated that target compounds exhibited weak tuberculostatic and antibacterial activities. Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI (50) values of 0.92-13 mu M.
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