Journal
MONATSHEFTE FUR CHEMIE
Volume 142, Issue 5, Pages 539-545Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-011-0456-z
Keywords
Ethyl thiophene-3-carboxylate; Thienopyrimidines; Thienopyridines; Tetrazole derivatives; Pyrazole derivatives; Antimicrobial activity
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The key intermediate ethyl 2-amino-5-benzoyl-4-methylthiophene-3-carboxylate was prepared by a Gewald reaction starting from benzoylacetone, sulfur, and ethyl cyanoacetate in the presence of diethylamine. This intermediate reacted with various reagents to afford different fused and polyfunctional substituted thiophenes. Antimicrobial screening of the synthesized compounds exhibited promising antimicrobial activities.
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