Journal
MONATSHEFTE FUR CHEMIE
Volume 143, Issue 1, Pages 161-164Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-011-0582-7
Keywords
FTY720; Immunosuppressant; Synthesis; Iron-catalyzed; Wittig reaction
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Funding
- new century excellent talents in university (NCET)
- Laboratory of Organic Functional Molecules, the Sino-French Institute of ECNU
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This paper describes a practical synthetic approach to preparation of an immunosuppressant, FTY720. The key steps involve an iron-catalyzed cross-coupling reaction and a Wittig reaction. The advantages of this synthesis include readily available starting materials, inexpensive reagents, simple operations and good yields.
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