Journal
MONATSHEFTE FUR CHEMIE
Volume 141, Issue 12, Pages 1339-1345Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-010-0397-y
Keywords
Nanocrystalline magnesium oxide; 2,4,5-Trisubstituted imidazoles; One-pot condensation; Solvent-free conditions
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Funding
- Research Council of the University of Kashan
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Nanocrystalline magnesium oxide with high specific surface area has been used as a novel and efficient catalyst for an improved and rapid synthesis of biologically active 2,4,5-trisubstituted imidazoles, by three-component, one-pot condensation of 1,2-diketones and aryl aldehydes, in excellent yields under solvent-free and conventional heating conditions. The method has several advantages, for example excellent yields, shorter reaction time, and use of a non-toxic and recyclable catalyst.
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