Journal
MONATSHEFTE FUR CHEMIE
Volume 140, Issue 6, Pages 619-623Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-008-0105-3
Keywords
Imatinib; Arylamine; Carboxylic acid; Amidation; Reduction
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A classical convergent approach for the synthesis of the anticancer drug imatinib has been substantially improved. Imatinib was assembled by coupling the amine and carboxylic acid precursors by using N, N'-carbonyldi-imidazole (CDI) as a condensing agent. Both intermediates have been synthesized by novel efficient methods.
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