4.2 Article

Amino acid derivatives, VII:: Synthesis and antiviral evaluation of α-amino acid esters bearing an indazole side chain

Journal

MONATSHEFTE FUR CHEMIE
Volume 139, Issue 3, Pages 289-297

Publisher

SPRINGER WIEN
DOI: 10.1007/s00706-007-0770-7

Keywords

indazole; regioisomers; amino acids; dipeptides; antiviral activity

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A series of peptide and dipeptide derivatives conjugated with an indazole residue were synthesized. The new compounds were evaluated in vitro for cytotoxicity against Hepatitis-A virus (HAV-27), Herpes Simplex virus-1 (HSV-1), and Hepatitis-B virus (HBV) and showed moderate to high activity.

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