Journal
MONATSHEFTE FUR CHEMIE
Volume 139, Issue 8, Pages 931-933Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-008-0872-x
Keywords
imidazo[1,2-a]pyridine; ammonium chloride; three-component reaction; isocyanide
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Ammonium chloride as a very inexpensive and readily available reagent efficiently catalyzes one-pot, three-component Groebke condensation reactions of aldehydes, isocyanides, and 2-aminopyridines or 2-aminopyrimidines in methanol to afford the corresponding imidazo[1,2-a]pyridines in high yields at room temperature.
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