Journal
MOLECULES AND CELLS
Volume 32, Issue 6, Pages 491-509Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.1007/s10059-011-0276-3
Keywords
apoptosis; cell signaling; cytochrome p450; mitochondria; NADPH oxidase; reactive oxygen species
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Funding
- Ministry of Education, Science and Technology/National Research Foundation of Korea (NRF) [2011-0025760, 2011-0006304, R15-2006-020-00000-0, R31-2008-000-10010-0, 2007-000-20004-00]
- Ministry for Health, Welfare and Family Affairs [1020180]
- Brain Korea 21 scholarship
- National Research Foundation of Korea [2010-0007002] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.
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