Journal
MOLECULES AND CELLS
Volume 32, Issue 6, Pages 549-554Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.1007/s10059-011-0173-9
Keywords
eve; Drosophila melanogaster; GAGA; pleiohomeotic; Polycomb group genes; PRE; segmentation genes
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Funding
- National Research Foundation of Korea
- Ministry of Education, Science and Technology [313-2008-2-C00727]
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Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.
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