Journal
MOLECULES AND CELLS
Volume 29, Issue 3, Pages 291-296Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.1007/s10059-010-0034-y
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Funding
- Plant Diversity Research Center of the Ministry of Science and Technology of the Korean Government [PF06305-00]
- Plant Signaling Network Research Center, Ministry of Education, Science and Technology/Korea Science and Engineering Foundation [2009-0079303/R0602484]
- BioGreen 21 program [20080401-034-041-008-01-00]
- Korean Research Foundation [KRF-2008-314-C00351]
- Brain Korea 21 fellowships
- National Research Foundation of Korea [2008-314-C00351] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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During brassinosteroid (BR)signaling in Arabidopsis, BSU1 (bri1 SUPPRESSOR1) phosphatase and BIN2 (BRASSINOSTEROID INSENSITIVE2) kinase regulate the signal intensity by determining the phosphorylation status of the transcription factors BZR1 (BRASSINAZOLE RESISTANT1) and BES1 (bri1 EMS SUPPRESSOR1). Here, we report hat BIN2 and BSU1 are nucleocy oplasmic regulators that modulate the subcellular localization of BES1, with differential activities between the nucleus and the cytosol.In our experiments, the nuclear BIN2 induced phosphoryla ion and nuclear expor of BES1 more efficiently than cytosolic BIN2.The cytoplasmic BSU1 mediated the dephosphorylation and nuclear translocation of BES1 more efficiently than the nuclear one. BSU1 compromised the dwarf phenotype of bri1-5, a weak allele of BRI1 (BR-INSENSITIVE 1) receptor kinase, more effectively when localized in the cytosol than in the nucleus in transgenic plants. In conclusion, the predominance of cytosolic BSU1 and nuclear BIN2 might be required for the efficient subcellular localization of BES1 in BR signaling.
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