Journal
MOLECULES AND CELLS
Volume 28, Issue 5, Pages 441-446Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.1007/s10059-009-0140-x
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Funding
- Korea Science and Engineering Foundation [2009-0083754]
- Korea Research Foundation [KRF-2008-313-C00736]
- Gwangju Institute of Science and Technology Systems Biology Infrastructure Establishment
- National Research Foundation of Korea [2008-313-C00736] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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During epididymal transit, mammalian sperm acquire selected proteins secreted by the epididymis. We previously showed that a disintegrin and metalloprotease (ADAM) 7 is expressed specifically in the epididymis and transferred to the sperm surface during epididymal transit. Here, we show that mouse ADAM7 secreted to the epididymal lumen is associated with membranous vesicles known as epididymosomes. Furthermore, we found that ADAM7 can be transferred directly from epididymal vesicles to sperm and that it is an integral plasma membrane protein in sperm. Thus, our study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.
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