Journal
MOLECULES
Volume 23, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules23092147
Keywords
lignans; heilaohu; tujia ethnomedicine; chemical characterization; cytotoxicity; antioxidant
Funding
- Hunan Province Universities 2011 Collaborative Innovation Center of Protection and Utilization of Huxiang Chinese Medicine Resources
- Hunan Provincial Key Laboratory of Diagnostics in Chinese Medicine
- National Natural Science Foundation of China [81673579]
- Shaanxi innovative talents promotion plan, technological innovation team [2018TD-005]
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Heilaohu, the roots of Kadsura coccinea, has a long history of use in Tujia ethnomedicine for the treatment of rheumatoid arthritis and gastroenteric disorders, and a lot of work has been done in order to know the material basis of its pharmacological activities. The chemical investigation led to the isolation and characterization of three new (1-3) and twenty known (4-23) lignans. Three new heilaohulignans A-C (1-3) and seventeen known (4-20) lignans possessed dibenzocyclooctadiene skeletons. Similarly, one was a diarylbutane (21) and two were spirobenzofuranoid dibenzocyclooctadiene (22-23) lignans. Among the known compounds, 4-5, 7, 13-15 and 17-22 were isolated from this species for the first time. The structures were established, using IR, UV, MS and NMR data. The absolute configurations of the new compounds were determined by circular dichroism (CD) spectra. The isolated lignans were further evaluated for their cytotoxicity and antioxidant activities. Compound 3 demonstrated strong cytotoxic activity with an IC50 value of 9.92 mu M, compounds 9 and 13 revealed weak cytotoxicity with IC50 values of 21.72 mu M and 18.72 mu M, respectively in the HepG-2 human liver cancer cell line. Compound 3 also showed weak cytotoxicity against the BGC-823 human gastric cancer cell line and the HCT-116 human colon cancer cell line with IC50 values of 16.75 mu M and 16.59 mu M, respectively. A chemiluminescence assay for antioxidant status of isolated compounds implied compounds 11 and 20, which showed weak activity with IC50 values of 25.56 mu M and 21.20 mu M, respectively.
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