Journal
MOLECULES
Volume 19, Issue 6, Pages 7169-7188Publisher
MDPI
DOI: 10.3390/molecules19067169
Keywords
bis-naphtho-gamma-pyrones; chaetochromin; asperpyrone; nigerone; fungi; biological activities
Funding
- National Basic Research Program of China [2013GB127800]
- Hi-Tech R&D Program of China [2011AA10A202]
- Special Fund for Agro-Scientific Research in the Public Interest of China [200903039-6]
- National Natural Science Foundation of China [31271996]
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Bis-naphtho-gamma-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-gamma-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-gamma-pyrones are also discussed.
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