Journal
MOLECULES
Volume 19, Issue 12, Pages 20391-20423Publisher
MDPI AG
DOI: 10.3390/molecules191220391
Keywords
alkaloids; marine invertebrates; anticancer; natural products; drug discovery
Funding
- European Commission through the FP7 Projects [229893, 311848]
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The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.
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