Journal
MOLECULES
Volume 19, Issue 11, Pages 17763-17772Publisher
MDPI
DOI: 10.3390/molecules191117763
Keywords
flavonoid; morin; Acridocarpus orientalis; Malpighiaceae; antioxidant; lipid peroxidation; cytotoxicity
Funding
- Oman Research Council (TRC) [ORG/CBS/12/004]
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Acridocarpus orientalis is an important medicinal plant for some of the locals of Arabian region. Very little is known about its phytochemical constituents. In the present study, we aimed to isolate bioactive chemicals from the crude methanolic extract of the aerial parts of A. orientalis. The extraction and isolation resulted in the purification of two flavonoids: morin (1) and morin-3-O-beta-D-glucopyranoside (2). The structure elucidation was carried out by extensive analysis of spectroscopic data and comparison with the reported data for the known constituents. The pure isolates were subjected to various biological assays for their bioactivities. The compounds 1 and 2 were significantly active against the growth of various pathogenic fungi and phytotoxic against lettuce seed at higher concentrations. Furthermore, the free radical scavenging activities, anti-lipid peroxidation, and cytotoxic effects against HepG2, HT29, and HCT116 cancer cell lines were also assayed and the results are presented in this paper.
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