Journal
MOLECULES
Volume 19, Issue 8, Pages 12368-12420Publisher
MDPI
DOI: 10.3390/molecules190812368
Keywords
natural product; cyclodepsipeptide; solid-phase synthesis; biological activity; total synthesis
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Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra- to decadepsipeptides, composed exclusively of alpha-amino- and alpha-hydroxy acids.
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