Journal
MOLECULES
Volume 19, Issue 11, Pages 18993-19006Publisher
MDPI
DOI: 10.3390/molecules191118993
Keywords
cytotoxic activity; cancer cell lines; apoptosis; mitochondrial membrane permeability; caspasa-3 activity; nordrimanes; drimanes; sesquiterpenes
Funding
- Innova-CORFO [09MCSS6683]
- DGIP of the Universidad Tecnica Federico Santa Maria [PAC 2014, PIIC 2013]
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Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 mu M of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.
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