4.6 Article

Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

Journal

MOLECULES
Volume 19, Issue 12, Pages 20382-20390

Publisher

MDPI AG
DOI: 10.3390/molecules191220382

Keywords

Clinacanthus nutans; sulfur-containing compound

Funding

  1. National Science Council of Taiwan [103-2320-B-037-005-MY2, 102-2320-B-037-012-MY2]
  2. China Medical University under the Aim for Top University Plan of the Ministry of Education, Taiwan

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Four new sulfur-containing compounds, named clinamides A-C (1-3), and 2-cis-entadamide A (4), were isolated together with three known compounds from the bioactive ethanol extract of the aerial parts of Clinacanthus nutans. These secondary metabolites possess sulfur atoms and acrylamide functionalities. The structures of the isolated components were established by interpretation of their spectroscopic data, especially 1D and 2D NMR.

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