Journal
MOLECULES
Volume 19, Issue 10, Pages 16102-16121Publisher
MDPI AG
DOI: 10.3390/molecules191016102
Keywords
resveratrol; nitric oxide; eNOS; SIRT1; Nrf2
Funding
- Collaborative Research Center [SFB 553]
- DFG (Deutsche Forschungsgemeinschaft), Bonn, Germany [LI-1042/1-1]
- Center for Translational Vascular Biology (CTVB)
- Center for Thrombosis and Hemostasis (CTH) - Federal Ministry of Education and Research of Johannes Gutenberg University Medical Center, Mainz, Germany [BMBF 01EO1003]
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Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.
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