Journal
MOLECULES
Volume 19, Issue 5, Pages 6080-6105Publisher
MDPI
DOI: 10.3390/molecules19056080
Keywords
diagnostic; exosomes; microvesicles; quantitative methods
Funding
- DOD [W911NF-10-2-0111, HDTRA1-13-C-0055]
- National Science Foundation of China [81201223]
- Guangdong Province Medical Research Foundation [A2012533]
- Guangdong Medical College Research Startup Fund [B2013001]
- Guangdong Medical College Integration of Industry, Education and Research [C2013004]
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Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities.
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