Journal
MOLECULES
Volume 19, Issue 8, Pages 11538-11559Publisher
MDPI
DOI: 10.3390/molecules190811538
Keywords
maslinic acid; phytochemical; phytoalexin; pentacyclic triterpene; biological effects; antitumor; antidiabetic; antioxidant; nutraceutical
Funding
- Ministerio de Ciencia e Innovacion, Spain [AGL2009-12866, AGL2013-41188-R]
- Generalitat de Catalunya, Spain [20095GR471, 20145GR1221]
- Ajuts de Personal Investigador en Formacio de la Universitat de Barcelona (APIF-UB)
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Maslinic acid is a pentacyclic triterpene found in a variety of natural sources, ranging from herbal remedies used in traditional Asian medicine to edible vegetables and fruits present in the Mediterranean diet. In recent years, several studies have proved that maslinic acid exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. Experimental models used for the assessment of maslinic acid effects include established cell lines, which have been often used to elucidate the underlying mechanisms of action, and also animal models of different disorders, which have confirmed the effects of the triterpene in vivo. Overall, and supported by the lack of adverse effects in mice, the results provide evidence of the potential of maslinic acid as a nutraceutical, not only for health promotion, but also as a therapeutic adjuvant in the treatment of several disorders.
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