Journal
MOLECULES
Volume 19, Issue 4, Pages 4301-4312Publisher
MDPI
DOI: 10.3390/molecules19044301
Keywords
Akebia trifoliata; nortriterpenoids; bacteriostatic activity; cytotoxicity; alpha-glucosidase inhibitor
Funding
- National Natural Science Foundation of China [30870248, 31270406, 81102351]
- Innovation Program of the Chinese Academy of Sciences [KSCX2-YW-N-0804, KSCX2-EW-J-28, YG2012050, Y39000AF03]
- Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences [211027]
Ask authors/readers for more resources
Two new 30-noroleanane triterpenes, 2 alpha,3 beta,20 alpha-trihydroxy-30-norolean-12-en-28-oic acid (1), 2 alpha,3 beta-dihydroxy-23-oxo-30-norolean-12,20(29)-dien-28-oic acid (2), were isolated from the pericarps of Akebia trifoliata, together with four known ones, 3 beta-akebonoic acid (3), 2 alpha,3 beta-dihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (4), 3 alpha-akebonoic acid (5) and quinatic acid (6). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the pericarps of A. trifoliata for the first time. Compounds 3-6 showed in vitro bacteriostatic activity against four assayed Gram-positive bacterial strains. In particular 3 showed antibacterial activity toward MRSA with a MIC value 25 mu g/mL, which was more potent than kanamycin (MIC 125 mu g/mL). No compounds showed antibacterial activity toward the three Gram-negative bacteria tested. Compounds 4 and 5 showed interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, with IC50 values ranging from 8.8 and 5.6 mu M, respectively. Compounds 1, 2, 5 and 6 were further revealed to show significant in vitro alpha-glucosidase inhibitory activity with IC50 values from 0.035 to 0.367 mM, which were more potent than the reference compound acarbose (IC50 0.409 mM).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available