Journal
MOLECULES
Volume 19, Issue 7, Pages 10177-10188Publisher
MDPI AG
DOI: 10.3390/molecules190710177
Keywords
celastrol C-6 derivatives; antitumor activity; in vitro; in vivo
Funding
- National Science and Technology Major Project in China [2011ZX11401-026]
Ask authors/readers for more resources
New six C6-celastrol derivatives were designed, synthesized, and evaluated for their in vitro cytotoxic activities against nine human cancer cell lines (BGC-823, H4, Bel7402, H522, Colo 205, HepG2 and MDA-MB-468). The results showed that most of the compounds displayed potent inhibition against BGC823, H4, and Bel7402, with IC(50)s of 1.84-0.39 mu M. The best compound NST001A was tested in an in vivo antitumor assay on nude mice bearing Colo 205 xenografts, and showed significant inhibition of tumor growth at low concentrations. Therefore, celastrol C-6 derivatives are potential drug candidates for treating cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available