Journal
MOLECULES
Volume 19, Issue 3, Pages 3193-3230Publisher
MDPI
DOI: 10.3390/molecules19033193
Keywords
bioconjugates; drug delivery; hyaluronic acid; anticancer agents; imaging agents; genes
Funding
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) finanziamento locale
Ask authors/readers for more resources
Hyaluronic acid (HA) is a naturally-occurring glycosaminoglycan and a major component of the extracellular matrix. Low levels of the hyaluronic acid receptor CD44 are found on the surface of epithelial, hematopoietic, and neuronal cells; it is overexpressed in many cancer cells, and in particular in tumor-initiating cells. HA has recently attracted considerable interest in the field of developing drug delivery systems, having been used, as such or encapsulated in different types of nanoassembly, as ligand to prepare nano-platforms for actively targeting drugs, genes, and diagnostic agents. This review describes recent progress made with the several chemical strategies adopted to synthesize conjugates and prepare novel delivery systems with improved behaviors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available