Journal
MOLECULES
Volume 19, Issue 9, Pages 13212-13224Publisher
MDPI AG
DOI: 10.3390/molecules190913212
Keywords
Colocasia esculenta (L.) Schott; aldose reductase; antioxidant; diabetic complication
Funding
- Business for Cooperative R&D between Industry, Academy, and Research Institute [C0135915]
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2009-0094071]
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2012R1A1A-2008842]
Ask authors/readers for more resources
The goal of this study was to determine the rat lens aldose reductase-inhibitory effects of 95% ethanol extracts from the leaves of C. esculenta and, its organic solvent soluble fractions, including the dichloromethane (CH2Cl2), ethyl acetate (EtOAc), n-butanol (BuOH) and water (H2O) layers, using DL-glyceraldehyde as a substrate. Ten compounds, namely tryptophan (1), orientin (2), isoorientin (3), vitexin (4), isovitexin (5), luteolin-7-O-glucoside (6), luteolin-7-O-rutinoside (7), rosmarinic acid (8), 1-O-feruloyl-D-glucoside (9) and 1-O-caffeoyl-D-glucoside (10) were isolated from the EtOAc and BuOH fractions of C. esculenta. The structures of compounds 1-10 were elucidated by spectroscopic methods and comparison with previous reports. All the isolates were subjected to an in vitro bioassay to evaluate their inhibitory activity against rat lens aldose reductase. Among tested compounds, compounds 2 and 3 significantly inhibited rat lens aldose reductase, with IC50 values of 1.65 and 1.92 mu M, respectively. Notably, the inhibitory activity of orientin was 3.9 times greater than that of the positive control, quercetin (4.12 mu M). However, the isolated compounds showed only moderate ABTS(+) [2,29-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)] activity. These results suggest that flavonoid derivatives from Colocasia esculenta (L.) Schott represent potential compounds for the prevention and/or treatment of diabetic complications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available