Journal
MOLECULES
Volume 20, Issue 1, Pages 1-23Publisher
MDPI
DOI: 10.3390/molecules20010001
Keywords
biomedical polymers; macromolecular conjugates of drugs; enzymatic ring opening polymerization; ionic liquids; biodegradable polyesters; drug delivery systems
Funding
- National Science Centre (Poland) [DEC-2013/11/N/NZ7/02342]
Ask authors/readers for more resources
Biodegradable or bioresorbable polymers are commonly used in various pharmaceutical fields (e.g., as drug delivery systems, therapeutic systems or macromolecular drug conjugates). Polyesters are an important class of polymers widely utilized in pharmacy due to their biodegradability and biocompatibility features. In recent years, there has been increased interest in enzyme-catalyzed ring-opening polymerization (e-ROP) of cyclic esters as an alternative method of preparation of biodegradable or bioresorbable polymers. Ionic liquids (ILs) have been presented as green solvents in enzymatic ring-opening polymerization. The activity, stability, selectivity of enzymes in ILs and the ability to catalyze polyester synthesis under these conditions are discussed. Overall, the review demonstrates that e-ROP of lactones or lactides could be an effective method for the synthesis of useful biomedical polymers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available