Journal
MOLECULES
Volume 19, Issue 4, Pages 4326-4337Publisher
MDPI
DOI: 10.3390/molecules19044326
Keywords
Illicium lanceolatum; Illiciaceae; germacrane sesquiterpenes; m-menthane monoterpene; absolute stereochemistry; proliferative promotion; SH-SY5Y
Funding
- National Mega-project for Innovative Drugs [2012ZX09301-002-001, 2012ZX09301-002-006]
- State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Open Project [GTZK201310]
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Three new germacrane sesquiterpenes and a new m-menthane monoterpene were isolated together with four known compounds from the pericarp of Illicium lanceolatum, an adulterant to star anise (Illicium verum). All compounds were isolated from Illicium plants for the first time. The absolute stereochemistry of all germacranes and m-menthane was established by a combination of NMR and the modified Mosher's ester method. The biological activity was evaluated on SH-SY5Y neuroblastoma cell line. (1S,5R,7R)-1,5-Dihydroxygermacra-4(15),10(14),11(12)-triene (at 62.5 mu M) and (1R,5R,7R)-1,5-dihydroxygermacra-4(15),10(14),11(12)-triene (at 15.6 mu M) promoted the proliferation of SH-SY5Y by 36.2% and 45.8%, respectively, after 48 h incubation, indicating potential neurotrophic activity.
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