Journal
MOLECULES
Volume 19, Issue 8, Pages 12320-12327Publisher
MDPI AG
DOI: 10.3390/molecules190812320
Keywords
Rumphella antipathies; rumphellaones B and C; caryophyllane-type sesquiterpenoid; anti-inflammatory activity
Funding
- National Museum of Marine Biology and Aquarium
- National Dong Hwa University
- Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- Ministry of Science and Technology [NSC101- 2320-B-291-001-MY3, MOST 103-2325-B-291-001]
- China Medical University under the Aim for Top University Plan of the Ministry of Education, Taiwan
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Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented gamma-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 mu g/mL.
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