Journal
MOLECULES
Volume 19, Issue 11, Pages 18025-18032Publisher
MDPI AG
DOI: 10.3390/molecules191118025
Keywords
dysidinoid A; meroterpenoid; anti-MRSA; Dysidea; marine sponge
Funding
- National Natural Science Fund for Distinguished Young Scholars of China [81225023]
- Shanghai Rising-Star program [14QA1402800]
- National Natural Science Fund of China [41106127, 81302691, 81172978]
- Shanghai Subject Chief Scientist program [12XD1400200]
- Science and Technology Commission of Shanghai Municipality [14431901300]
- National High Technology Research and Development Program of China (863 Projects) [2013AA092902]
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An unusual meroterpenoid, dysidinoid A (1), was isolated from the South China Sea sponge Dysidea sp. Its structure was elucidated by extensive spectroscopic methods including HRESIMS and 2D NMR, and its absolute configuration was determined by single-crystal X-ray diffraction analysis. Dysidinoid A (1) is the first meroterpenoid from Nature bearing a 9,4-friedodrime skeleton and a 2,5-dionepyrrole unit. Dysidinoid A (1) showed potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) with MIC90 values of 8.0 mu g/mL against both.
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