Journal
MOLECULES
Volume 18, Issue 8, Pages 8845-8857Publisher
MDPI
DOI: 10.3390/molecules18088845
Keywords
Suzuki cross coupling; benzothiazoles; urease activity; nitric oxide scavenging activity
Funding
- HEC Pakistan
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In general, benzothiazole derivatives have attracted great interest due to their pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 mu g/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d] thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100 mu g/mL.
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