Journal
MOLECULES
Volume 18, Issue 5, Pages 5142-5154Publisher
MDPI AG
DOI: 10.3390/molecules18055142
Keywords
multicomponent reactions; 1,3-dipolar cycloaddition; azomethine ylide; dispirooxindole
Funding
- Natural Science Foundation of China [81102325]
- China Postdoctoral Science Foundation [2012T50781]
- Young Teachers Fund of Sichuan University [2011SCU11108]
- Sichuan Provincial Health Department Research Project [110173]
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An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an alpha-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
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