Journal
MOLECULES
Volume 18, Issue 11, Pages 14268-14284Publisher
MDPI AG
DOI: 10.3390/molecules181114268
Keywords
DNA; RNA; phosphoramidites; H-phosphonates; boranephosphonates; metallophosphonates; boranealkylphosphines
Funding
- National Institutes of Health
- National Science Foundation
- American Cancer Society
- University of Colorado
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The chemical synthesis of DNA and RNA is universally carried out using nucleoside phosphoramidites or H-phosphonates as synthons. This review focuses on the phosphorus chemistry behind these synthons and how it has been developed to generate procedures whereby yields per condensation approach 100% with very few side products. Additionally the synthesis and properties of certain DNA and RNA analogs that are modified at phosphorus will also be discussed. These analogs include boranephosphonates, metallophosphonates, and alkylboranephosphines.
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