Journal
MOLECULES
Volume 18, Issue 8, Pages 8858-8872Publisher
MDPI
DOI: 10.3390/molecules18088858
Keywords
flavonoids; glutathione; antioxidant activity; synergism; antagonism
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT) [PEst-C/EQB/LA0006/2011]
- FCT [PTDC/AGR-AAM/102908/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/AGR-AAM/102908/2008] Funding Source: FCT
Ask authors/readers for more resources
Polyphenols are able to trap free radicals, which contributes to their known antioxidant capacity. In plant extracts, these secondary metabolites may act in concert, in a way that their combined activities will be superior to their individual effects (synergistic interaction). Several polyphenols have demonstrated clear antioxidant properties in vitro, and many of their biological actions have been attributed to their intrinsic reducing capabilities. As so, the intake of these compounds at certain concentrations in the diet and/or supplementation may potentiate the activity of reduced form glutathione (GSH), thus better fighting oxidative stress. The aim of this work was to predict a structure-antioxidant activity relationship using different classes of flavonoids and to assess, for the first time, possible synergisms and antagonisms with GSH. For these purposes a screening microassay involving the scavenging of DPPH center dot was applied. In general, among the tested compounds, those lacking the catechol group in B ring showed antagonistic behaviour with GSH. Myricetin displayed additive effect, while quercetin, fisetin, luteolin, luteolin-7-O-glucoside, taxifolin and (+)-catechin demonstrated synergistic actions. Furthermore, adducts formed at C2' and C5' of the B ring seem to be more important for the antioxidant capacity than adducts formed at C6 and C8 of the A ring.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available