Journal
MOLECULES
Volume 18, Issue 3, Pages 3615-3629Publisher
MDPI AG
DOI: 10.3390/molecules18033615
Keywords
oleanolic acid; oxime ester; glucosamine-6-phosphate synthase; anti-fungal activity
Funding
- NSFC of China [21172257]
- National Basic Research Program of China [2010CB126105]
- National High Technology Research Program of China [2011AA10A206, 2011BAE06B02-01, 2012BAK25B03-01]
- Chinese Universities Scientific Fund [2011JS030]
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In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds were confirmed by MS, HRMS, H-1-NMR and C-13-NMR. Preliminary studies based on means of the Elson-Morgan method indicated that many compounds exhibited some inhibitory activity of glucosamine-6-phosphate synthase (GlmS), and the original fungicidal activities results showed that some of the compounds exhibited good fungicidal activities towards Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn and Botrytis cinerea Pers at the concentration of 50 mu g/mL. These compounds would thus merit further study and development as antifungal agents.
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