Journal
MOLECULES
Volume 18, Issue 6, Pages 6521-6531Publisher
MDPI
DOI: 10.3390/molecules18066521
Keywords
microfluidics; emulsion; droplet; microparticles; phenol formaldehyde resin; polycaprolactone; chitosan
Funding
- National Science Council of Taiwan, R.O.C.
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This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e. g., polycaprolactone) and nonsolvent-dependent (e. g., chitosan) microparticles were successfully prepared. The size of emulsion droplets could be easily adjusted by tuning the flow rates of the dispersed/continuous phases. After evaporation, polycaprolactone microparticles ranging from 29.3 to 62.7 mu m and chitosan microparticles ranging from 215.5 to 566.3 mu m were obtained with a 10% relative standard deviation in size. The proposed PFR microfluidic platform has the advantages of active control of the particle size with a narrow size distribution as well as a simple and low cost process with a high throughput.
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