Journal
MOLECULES
Volume 17, Issue 3, Pages 2704-2713Publisher
MDPI AG
DOI: 10.3390/molecules17032704
Keywords
Rosmarinus officinalis L.; 1,8-cineole; alpha-pinene; beta-pinene; antibacterial activities; cytotoxicity
Funding
- special scientific fund for non-profit public industry [201204601]
- Fundamental Research Funds for the Central Universities [DL09BA23, DL09BA30]
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In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), alpha-pinene (19.43%) and beta-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to alpha-pinene, and a little bit better than beta-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025%, 0.076% and 0.13% (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.
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