Journal
MOLECULES
Volume 17, Issue 9, Pages 11146-11155Publisher
MDPI
DOI: 10.3390/molecules170911146
Keywords
indole alkaloids; Trypanosoma cruzi; Bacillus pumilus; Chagas disease
Funding
- National Secretariat for Science and Technology of Panama (SENACYT) [COL08-061, COL09-047]
- INDICASAT-AIP
- Fogarty International Center's International Cooperative Biodeversity Groups program [TW006634]
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Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), N-acetyl-beta-oxotryptamine (3), cyclo-(L-Phe-L-Pro) (4), and 3-formylindole (5). The structures of compounds 1-5 were established by spectroscopic analyses, including HRESITOF-MS and NMR (H-1, C-13, HSQC, HMBC and COSY). Compounds 2, 3 and 5 caused the inhibition on the growth of Trypanosoma cruzi (T. cruzi), with IC50 values of 20.6, 19.4 and 26.9 mu M, respectively, with moderate cytotoxicity against Vero cells. Compounds 1-5 were found to be inactive when tested against Plasmodium falciparum and Leishmania donovani, therefore showing selectivity against T. cruzi parasites.
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