Journal
MOLECULES
Volume 18, Issue 1, Pages 41-49Publisher
MDPI
DOI: 10.3390/molecules18010041
Keywords
Acanthopanax sessiliflorus; lignan; acanthosessilin A; nitric oxide
Funding
- NIHH
- Cooperative Research Program for Agricultural Science & Technology Development, Rural Development Administration, Korea [PJ008700]
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A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (H-1, C-13, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
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