Journal
MOLECULES
Volume 17, Issue 10, Pages 11379-11390Publisher
MDPI
DOI: 10.3390/molecules171011379
Keywords
medicinal plants; antiprotozoal; antiplasmodial; antileishmanial; antitrypanosomal; crude extracts; Saudi Arabia
Funding
- NPST program by King Saud University [10-MED1288-02]
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The present study investigated the in vitro antiprotozoal activity of sixteen selected medicinal plants. Plant materials were extracted with methanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxic activity was determined against MRC-5 cells to assess selectivity. The criterion for activity was an IC50 < 10 mu g/mL (<5 mu g/mL for T. brucei) and a selectivity index of >= 4. Antiplasmodial activity was found in the extracts of Prosopis juliflora and Punica granatum. Antileishmanial activity against L. infantum was demonstrated in Caralluma sinaica and Periploca aphylla. Amastigotes of T. cruzi were affected by the methanol extract of Albizia lebbeck pericarp, Caralluma sinaica, Periploca aphylla and Prosopius juliflora. Activity against T. brucei was obtained in Prosopis juliflora. Cytotoxicity (MRC-5 IC50 < 10 mu g/mL) and hence non-specific activities were observed for Conocarpus lancifolius.
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