Journal
MOLECULES
Volume 17, Issue 9, Pages 10094-10107Publisher
MDPI
DOI: 10.3390/molecules170910094
Keywords
microparticles; pomegranate; antifungal activity; Candida albicans
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Financiadora de Estudos e Projetos (FINEP)
- Capacitacao e Aperfeicoamento de Pessoal de Nivel Superior, (Capes)
- Fundacao Araucaria
- Programa de Pos-graduacao em Ciencias Farmaceuticas da Universidade Estadual de Maringa
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Pomegranate has attracted interest from researchers because of its chemical composition and biological properties. It possesses strong antioxidant activity, with potential health benefits, and also antimicrobial properties. The aim of this study was to produce microparticles containing pomegranate extract by the spray-drying technique, utilizing alginate or chitosan as encapsulating agents. Characterization and antifungal assays were carried out. Production yields were about 40% for alginate microparticles and 41% for chitosan. Mean diameters were 2.45 mu m and 2.80 mu m, and encapsulation efficiencies were 81.9% and 74.7% for alginate and chitosan microparticles, respectively. The spray-drying process preserved the antifungal activity against Candida albicans. These results could be useful for developing dosage forms for treating candidiasis, and should be further investigated in in vivo models.
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